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Dr. Mark D. Womble

Dr. Mark D. Womble
Professorpicture of Dr. Mark Womble
Anatomy and Physiology
Graduate Program Director

330-941-4727
mdwomble AT ysu DOT edu
WBSH 4063

B.S.   Texas Christian University, 1975
M.S.   University of Kentucky, 1978
Ph.D.  University of Michigan, Anatomy and Cell Biology, 1983


Research

Research in my lab utilizes microscopic anatomy (histological) techniques for the sectioning, staining, and analysis of organs and tissues.  Our primary project is investigating the ability of stem cells to promote wound healing.  Following surgery, incisional wounds of the abdominal wall are subject to considerable stress during normal body movements.  Thus a common complication is slow healing or even re-opening of the wound, which may require additional surgery.  As the wound heals, it gradually becomes stronger as collagen fibers (scar tissue) develop across the wound site.  Dr. Diana Fagan (Biological Sciences) is using a rat model to examine the ability of bone marrow-derived adult stem cells to enhance the healing of abdominal wall wounds.  Following suturing of the incision, the wound is treated with varying doses of stem cells and allowed to heal for 4 or 8 weeks.  Working in collaboration with Dr. Fagan, my lab is using different histological stains to visualize and quantify the amount and density of collagen fibers found at the wound site.  Preliminary data indicates that stem cells do speed the deposition of collagen and thus aid in wound healing.

Selected Publications

Olson RA, Womble MD, Thomas DR, Glenn ZD, Butcher MT. (2015). Functional morphology of the forelimb of the nine-banded armadillo (Dasypus novemcinctus): Comparative perspectives on the myology of Dasypodidae. Journal of Mammalian Evolution (in press).

Womble, M.D. (2013) Chapter 7: The Axial Skeleton. Open Stax College Anatomy and Physiology online textbook, Words and Numbers, Inc.

Womble, M.D. (2013) Chapter 8: The Appendicular Skeleton. Open Stax College Anatomy and Physiology online textbook, Words and Numbers, Inc.

Womble, M.D. (2013) Chapter 9: Joints of the Body. Open Stax College Anatomy and Physiology online textbook, Words and Numbers, Inc.

Riblet, R., Kaur, A., Kaur, H., and Womble, M.D. (2010).  The anticonvulsant drug retigabine enhances M-current and reduces neuronal excitability in bullfrog sympathetic neurons.  BIOS 81 (2): 55-61.

Womble, M.D., Andrews, J.A., and Crook, J.J. (2002) 17-b Estradiol reduces excitatory postsynaptic potential (EPSP) amplitude in rat basolateral amygdala neurons.  Neuroscience Letters 331: 83-86.

Moises, H.C., Womble, M.D., Washburn, M.S. & Williams, L.R. (1995). Nerve growth factor facilitates cholinergic neurotransmission between nucleus basalis and the amygdala: An electrophysiological study. Journal of Neuroscience 15: 8131-8142.

Womble, M.D. and Moises, H.C. (1994). Metabotropic glutamate receptor agonist ACPD inhibits some, but not all, muscarinic-sensitive K+ conductances in basolateral amygdaloid neurons. Synapse 17: 69-75.

Womble, M.D. and Moises, H.C. (1993). Hyperpolarization-activated currents in neurons of the rat basolateral amygdala. Journal of Neurophysiology 70: 2056-2065.

Womble, M.D. and Moises, H.C. (1993). Muscarinic modulation of conductances underlying the afterhyperpolarization in neurons of the rat basolateral amygdala. Brain Research  621: 87-96.

Womble, M.D. and Moises, H.C. (1992). Muscarinic inhibition of M-current and a potassium leak conductance in neurons of the rat basolateral amygdala. Journal of Physiology  457: 93-114.

Womble, M.D. and Wickelgren, W.O. (1990). Inhibition of a cAMP-dependent Ca2+-activated K+ conductance by forskolin prolongs Ca2+ action potential duration in lamprey sensory neurons. Brain Research  518: 135-142.

Womble, M.D. and Wickelgren, W.O. (1989). Activation of adenylate cyclase by forskolin prolongs calcium action potential duration in lamprey sensory neurons. Brain Research  485: 89-94.

Womble, M.D. and Roper, S. (1987). Neonatal synapse elimination in the rat submandibular ganglion: Effects of retarded target growth. Journal of Neurophysiology 58: 288-299.

Womble, M.D. and Roper, S. (1987). Retrograde effects of target atrophy on submandibular ganglion neurons. Journal of Neurophysiology 58: 276-287.

Womble, M.D. (1986). The clustering of acetylcholine receptors and formation of neuromuscular junctions in regenerating mammalian muscle grafts. American Journal of Anatomy 176: 191-205.

Womble, M.D. and Bonner, P.H. (1980). Developmental fate of a distinct class of chick myoblasts after transplantation of cloned cells into quail embryos. Journal of Embryology and Experimental Morphology  58: 119-130.

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