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Dr. Ganesaratnam K. Balendiran
Associate Professor
Biochemistry
330-941-7103
e-mail: gkbalendiran AT ysu DOT edu
WBSH 6017
Link to Homepage
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Ph.D.: University of Wisconsin-Madison, 1991
Postdoctoral:
Cold Spring Habor Laboratory, NY
Research Interests: Function and activity of biological molecules related to physical and biological properties. Sugar metabolism, nucleotide metabolism and gene regulation.
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Selected Recent Publications (for a complete list see here):
Verma, M., Martin, H-J., Haq, W., O'Connor, T. R., Maser, E., Balendiran, G. K. Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers. Eur. J. Phar 584/2-3: 213-221 (2008).
Balendiran, G.K., Verma, M., Perry, E. Chemistory of fibrates. Current Chemical Biology, 3: 311-316, (2007).
Balendiran, G. K., Verma, M., Bharadwaj, S. Lead Optimization in the Design of Aldose Reductase Inhibitors. In Enzymology and Molecular Biology of Carbonyl Metabolism. Henry Weiner Eds. P228-237, (2007).
Klemin, S., Calvo, R. Y., Bond, S., Dingess, H., Rajkumar, B., Perez, R., Chow, L., Balendiran, G. K. WY 14,643 inhibits human aldose reductase activity. Journal of Enzyme Inhibition and Medicinal Chemistry, 21: 569-573, (2006).
Sawaya, M.R., Zhu, Z., Mersha, F., Chan, S-H., Dabur, R., Xu, S-Y., Balendiran, G.K. Crystal structure of the restriction-modification system control element C.BclI and mapping of its binding site. Structure 13:1837-1847, (2005).
Marquardt, T., Kostrewa, D., Balakrishnan, R., Gasperina, A., Kambach, C., Podjarny, A., Winkler, F. K., Balendiran, G.K. and Li, X-D. High-resolution Crystal Structure of AKR11C1 from Bacillus halodurans: An NADPH-dependent 4-Hydroxy-2,3-trans-nonenal Reductase. J. Mol. Biol. 354:304–316, (2005).
Balendiran, G.K., Rajkumar, B., Fibrates inhibit aldose reductase activity in the forward and reverse reactions. Biochemical Pharmacology 70:1653-1663, (2005).
Balendiran, G.K., Rajkumar, B. In search of aldose reductase inhibitors, In Enzymology and Molecular Biology of Carbonyl Metabolism. Henry Weiner Eds. P276-283, (2005).
Rath, N.P., Haq, W., and Balendiran, G.K. Fenofibric acid. Acta Cryst C61:o81-o84, (2005).
Balendiran, G.K., Dabur, R.S. and Fraser, D. A. Role of Glutathione in Cancer. Cell Biochemistry and Function. 22:343 – 352, (2004).
Studebaker, A.W., Ariza, M.E., Balendiran, G.K. and Williams, M.V. Novel Approaches for Modulating dUTPase and Uracil-DNA Glycosylase: Potential Uses for Cancer and Viral Chemotherapy. Drug Design Reviews - Online, 1:1-13, (2004).
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